3. Exercise Ball Crunch: This is one of the most effective ways to strengthen and flatten abs.  Studies show this exercise is 40% more effective than regular ab crunches as it targets smaller muscles for flat toned abs including the oblique’s for a small waist and the outermost muscles that your typical ab crunch may miss.  To begin, lie down on the ball positioning it under the lower back.  Place arms behind your head.  Tighten your abs as you lift your torso off the ball while keeping the ball stable.  Lower back down and repeat 15 times with 1-3 sets.
55. Have 1 Healthy Snack At Work Per Day – Bringing a snack to work eliminates the temptation to buy less healthy options. Some great choices include an apple, hummus and veggies, hardboiled eggs, turkey jerky, or plain greek yogurt with berries. This should help keep your energy levels high while keeping your hunger under control until dinner time. Here are 25 awesome snack ideas to choose from.
Make sure that everything you're eating is whole — as in nothing processed or packaged. Since salt is a preservative, these are the foods that are highest in sodium — something to keep in mind when planning your meals. Plan on making sure that all items you choose are fresh. That means filling up on fresh fruits and veggies, whole grains, low-fat dairy, and lean protein.
Just like being underweight isn't healthy, losing it too fast is unhealthy, too, especially if you're on an extreme calorie deficit. "The American College of Sports Medicine recommends one to two pounds of fat loss per week," said Jim White, RD, ACSM, owner of Jim White Fitness and Nutrition Studios. Although people who weigh more can lose weight quicker, if you are feeling tired, dizzy, or irritable, or dropping as much as five to 10 pounds a week, then you might be losing weight too fast.

The scale is not necessarily your friend. You may want to lose fat – but the scale measures muscles, bone and internal organs as well. Gaining muscle is a good thing. Thus weight or BMI are imperfect ways to measure your progress. This is especially true if you’re just coming off a long period of semi-starvation (calorie counting), as your body may want to restore lost muscles etc. Starting weight training and gaining muscle can also hide your fat loss.
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Açai berry powder is high in anthrocyanin- a natural pigment providing powerful antioxidants. Açai provides an array of minerals that help to keep your body healthy and gives you high levels of sustainable energy. This extra energy will enable you to get out and exercise more, therefore extra calories will be burned and eventually the fat will come off your tummy!

In addition to improving your health, maintaining a weight loss is likely to improve your life in other ways. For example, a study of participants in the National Weight Control Registry* found that those who had maintained a significant weight loss reported improvements in not only their physical health, but also their energy levels, physical mobility, general mood, and self-confidence.
78. Take A 30-Minute Walk During Lunch – Walking after a meal may help you control blood sugar levels and aid weight loss.62 Start by taking a 30-minute walk after you eat lunch. You can also do this after dinner, instead of just sitting on the couch and watching TV. The added benefit is that you’ll get outside to breathe the fresh air and get some sunshine.
Getting enough protein every day, whether you’re in a quick-fix or long-term mindset is important for keeping your muscles and metabolism healthy throughout weight loss. Make sure you’re having some chicken breast, lean ground turkey, fish, seafood or tempeh that’s the size of a deck of cards at every meal. When snacking, have 2 eggs, 1/4 cup of nuts, or 3/4 cup of Greek yogurt or cottage cheese to meet your protein needs and stay full and feel slim.

We wanted to know what these studies found and, most importantly, when all the science and evidence were boiled down, what experts recommend for people who would like to shed pounds in a safe, healthy manner. All of the experts emphasized one thing: A person's approach to weight loss should be one that is enjoyable and can be maintained over the long term. Weight loss shouldn't be about deprivation, because diets that deprive people of their favorite foods tend to be short-lived, said Dr. Pieter Cohen, an assistant professor of medicine at Harvard Medical School and general internist at Cambridge Health Alliance. 
If not bothersome I’d like to ask you a specific question that I don’t believe I’ve seen on your website. I know the sole factor of fat loss is calorie deficit and am happy with the weight loss I’ve achieved in the past 9 weeks. I will attend a friend’s wedding for a week next week and don’t imagine I will be able to maintain my current diet. I’ve read from other sources discussing how you should “SLOWLY” increase your calorie consumption to avoid your body storing fat. I will certainly not eat 4,000 calories during my trip but my question will be if it’s OK for me to jump back to “maintenance level” calorie consumption or you would recommend me doing “15% Deficit on Day 1, 10% Deficit on Day 2…etc.”?
He's laughing at you - all of you, and he knows that all he has to do is stay fat and you'll loving care for him. Being fat is his job but when he gets bored with it - and he will, you will be the ones he blames.Nobody forced him to become the pig he is. if you pander to him he will just continue. He isn't ill, and definitely not stupid. He doesn't deserve compassion but desperately needs tough love.Kick him out on the street, he's had enough free service now it's time to pick up the tab.If he lives, he lives - if he dies, dies. I, nor anybody else truly cares
33. Shop The Perimeter Of The Grocery Store – Grocery stores keep all of good stuff on the perimeter.36 It’s here that you’ll find your fruits, vegetables, and lean proteins. The aisles are usually filled with highly-palatable processed foods containing a combination of fat, salt, sugar, and a ton of calories. Only venture into these sections when you have your grocery list in hand so you’ll know exactly what you need.
Spoon Guru nutritionist Isabel Butler (MSc, ANutr) recommends that “the best way to reduce weight and maintain the weight loss is by simply eating a balanced and healthy diet, without refusing yourself particular foods… If you do cut out foods, you need to make sure your diet is still balanced and you are getting the nutrients your body needs from other sources.”  
“If a client has come to me looking to lose 10 pounds, I would tell them to simply move. Move more, and more often. Walk or bike ride to class or work, even park further away from your location in the parking lot. Take the stairs or take a walk during lunch. You don’t have to spend hours every day in the gym sweating, but you do have to make a conscious effort to move more, and sit less. This works great because it doesn’t feel like work and you’re burning more and more calories throughout the day.” — Ajia Cherry, personal trainer and Founder at Functional Innovative Training
As an alternative to eating a reduced-calorie diet every day, some people try to do "intermittent fasting." This means they significantly cut their calories on a few days per week and eat normally the other days. This diet is generally not recommended, but early research suggests that some people may find it easier to follow this diet than a traditional one, Tallmadge said. A review study published in April 2015 found that people on intermittent-fasting diets lost about 9 percent of their body weight over six months, and about 80 percent of the participants were able to stick with the diet.
Trim Portions. If you did nothing else but reduce your portions by 10%-20%, you would lose weight. Most of the portions served both in restaurants and at home are bigger than you need. Pull out the measuring cups to get a handle on your usual portion sizes, and work on paring them down. Get instant portion control by using small bowls, plates, and cups, says Brian Wansink, PhD, author of Mindless Eating. You won't feel deprived because the food will look plentiful on dainty dishware.
So i dont have ins & cant go to doc right now so im begging u not to tell me to “see my doc”; i’ll give u all the info u want right here. Point blank: at 4’4″, mother of a toddler & 29 yrs old w/ hypothyroidism, how many cals do u suggest? Im not gonna “drink my cals” like my health nut cousin says; good point, why waste those precious few on dp? Water for me, thank u! And im not giving up exercising just cuz i “can & still lose weight” based on cal def. (Quotes not meant in derogatory tone by any means.)
To lose weight, start cooking instead of eating out! Incorporate lots of lean proteins and fresh fruits and veggies. Stick to recommended portion sizes on food labels and recipes, use smaller plates for your meals, and save snacking for when you’re hungry, not just bored. Burn calories by walking or jogging 3 times per week and mixing in strength training, like squats and free weights, every few days. Use weight tracking apps to calculate your daily calories, doing your best to burn more than you eat!
Real talk: It could take weeks or months to see the metabolic effects of exercise on the scale, and even then, building muscle, which is denser than body fat, could lead to weight gain. “Do what you like because it’s good for you,” Dr. Seltzer says, noting the way exercise is awesome for your heart, mental health, and more—and that not all measure of progress can be seen on the scale.

Crash dieting can backfire and actually make it harder to lose weight—not to mention increase the chance you'll gain it back when you start eating again. At the same time, if you're cutting out calories without assessing and ensuring you're still eating the right ones, "you actually stop losing weight," Cederquist says. You can also feel weak, lightheaded and fatigued, like you're running off fumes. Not exactly the best motivation to hit the gym.
This study divided its subjects up into 2 groups, and had them both create the same sized caloric deficit. HOWEVER, the difference between them was the manner in which this deficit was created. One group did it by eating less total calories (diet alone), but the other group did it by eating less total calories AND burning more calories by doing cardio (a combination of diet AND exercise). But again, the total weekly caloric deficit was the same for both groups. Guess what happened? They all lost the same amount of weight and body fat. Why? Because a deficit of X calories is a deficit of X calories regardless of whether you burned those calories off via cardio or just didn’t eat them in the first place. Fat loss isn’t about how you create the deficit, it’s just about the deficit itself.
Much of what we understand about weight regulation comes from studies of rodents, whose eating habits resemble ours. Mice and rats enjoy the same wide range of foods that we do. When tasty food is plentiful, individual rodents gain different amounts of weight, and the genes that influence weight in people have similar effects in mice. Under stress, rodents eat more sweet and fatty foods. Like us, both laboratory and wild rodents have become fatter over the past few decades.
68. Sleep In A Cool, Dark Room – Sleep is optimized in a room that’s between 60-67F, and that’s as dark as possible. Artificial light suppresses the secretion of melatonin, the hormone that makes you tired. Creating the optimal sleep environment in your room can greatly increase the duration and quality of your sleep, which can help with weight loss.57
The weight loss market is overflowing with diet aids that all claim to help you lose weight quickly. Shakes, snacks and pills marketed as appetite suppressants and weight loss programs litter the shelves of most stores today. Unfortunately, the desire to lose weight often causes people to forget that weight loss is most beneficial to the body when it is done in a safe and healthy manner. Weight loss is also more sustainable when it's achieved with lifestyle changes over a long period of time.[1]
We're now into a section about attitude. Yes! The right attitude can help you lose weight, however all of the generalizations about "most obese people." I'm really getting sick of being lumped into this arbitrary generalization. Really, again, where is the research that shows that most obese people think this and do this. Is it really most? Sorry, but everyone I know knows how freaking hard it is and we're sick of people telling us what we think. Really, it's not the problem. We know it's hard, we know we're eating the wrong stuff, we know we don't exercise enough. Stop putting words in our mouths, your assumptions are just another reason we're not motivated to lose weight...again completely counter to what the book promises when it says this book will motivate you. Um, no shaming and putting words in my mouth doesn't really motivate.
"It’s easy to become impatient and frustrated when you’re trying to lose weight and haven’t seen the results yet. But be realistic – you won’t see the affect overnight. Your brain’s wiring plays a huge part in resisting changes in lifestyle, and it takes time to establish new habits – up to 12 weeks. Stick with it for at least eight weeks and you should notice a change."
A dietitian can help assess what balance of macronutrients you need. But it's also important to talk to your other doctors when you're cutting calories, especially if you're making a huge change, to make sure it won't affect any current medications you take or conditions you have. Losing weight may be your No. 1 goal, but maintaining your health throughout the process is just as—if not more—important.
18. Walk 7,500+ Steps Every Day – Use a pedometer or fitness tracker to count your daily steps, which will incrementally help you lose weight.23 If you have an iPhone, there is a health app that automatically counts your steps. Otherwise, you can download a pedometer app for your smartphone, or buy one of the many fitness trackers on the market. In general, the more active you are, the more weight you will lose. Consider walking in the morning, during lunch, or after-dinner to exceed 7,500 steps per day.
Hey its me again; im addicted to ur site! You make everything clear & u have so much for us to read! (I get sidetracked & lost lol). So pls help me this way. Im totally in love with the “eat whatever you want just less of it” method. My doc basically told me the same thing as a child. “Instead of a big whopper, eat a whopper jr.” I’ve already cut down on my dp; i only had 16 oz yesterday! Yay! But now im stuck. Remember? Im a little person. (29 yrs old, 4’4″). Soooo from another source on the subject (& common sense) i should be eating HALF of what avg height ppl eat, right? Like if theirs is 2000, mine should be 1000, right? And then on top of that, a cal def, sooo 980?? Idk. Im not giving up my evening walks or other exercises (which i’ve just included beginners pilates.) (We’re talkin im starting from the ground up. . . From the ground lying-face-down up lol).
3. Calculate your target daily calorie intake – Once you have a sense of your eating habits, you can calculate your target calorie intake to ensure you create a calorie deficit. Remember, if you don’t eat fewer calories than you burn, you will not lose weight. Our recommendation is to multiply your bodyweight by 10. If you’re a man with over 25% body fat, or a woman with over 30%, subtract 200 calories from the target calorie number. For more information, you can check out How Many Calories Should I Eat To Lose Weight? and also How To Calculate Your Calorie Burn.
You don’t have to go low-carb to ditch those extra pounds around your waist in a short period of time. In fact, opting for more whole grains might just get you there faster. Researchers at Tufts University have linked eating three or more daily servings of whole grains to as much as a 10 percent reduction in visceral body fat, the kind that ups your risk for chronic diseases, like diabetes, heart disease, and high blood pressure.
At any given time, there are dozens of weight-loss hypes in the marketplace that claim to take off 10 pounds in 10 days, or whatever. Desperation can tempt us to try anything — from "clean eating" to cutting out food groups entirely. Keep in mind: Just because an avocado-walnut-"crunchy"-kale-salad dripping in coconut oil is deemed "clean" by a so-called "expert" on your Instagram feed does not make it an unlimited food. Moral of the story? Avoid fads, eat real food, watch some Netflix, and unwind (perhaps with a glass of wine in hand). Now that's my kind of detox.
19. Actively Commute To Work – If you can, walk, bike, or run to work instead of taking a car. This is a great way to increase your daily energy expenditure, spend some time outdoors, and wake up before work. Commuting daily by car has been found to contribute to an average weight gain of about 5 lbs over 4 years.24 So if you have the option, actively commute to work.
What happens if you fast for a day? What happens if you don't eat for a day? While most people will feel hungry and possibly tired, there is also a range of other effects. In this article, learn about how the body starts to burn fat for energy and whether fasting for 24 hours can be a good weight loss tool. We also investigate the possible risks. Read now
It sounds silly, but switching which hand you eat with can save you calories, and help boost weight loss. “It takes 15 minutes for your brain to realize that you’re full,” celebrity personal trainer Jay Cardiello told us in our article 40 Weight Loss Tips for Over 40. “To give your mind time to catch up to your mouth, simply switch your fork to non-dominate hand. It may be frustrating, but it’s a simple and unnoticeable way to curb overeating and lose weight.”
You’ve heard of a self-fulfilling prophecy? If you keep focusing on things you can’t do, like resisting junk food or getting out the door for a daily walk, chances are you won’t do them. Instead (whether you believe it or not) repeat positive thoughts to yourself. “I can lose weight.” “I will get out for my walk today.” “I know I can resist the pastry cart after dinner.” Repeat these phrases and before too long, they will become true for you.
You might feel silly, but it works. When Alan R. Hirsch, MD, neurological director of the Smell & Taste Treatment and Research Foundation in Chicago, tried this with 3,000 volunteers, he found that the more frequently people sniffed, the less hungry they were and the more weight they lost—an average of 30 pounds each. One theory is that sniffing the food tricks the brain into thinking you’re actually eating it. Use these other tricks to become a more mindful eater.
1. Bicycle Crunches are a great ab exercise and work the abs from every angle. It’s a combination of the regular crunch, a side-to-side motion that hits the oblique muscles and a reverse crunch that targets the lower abs. You can change the difficulty level by increasing or decreasing the range of motion used and the speed of movement as well as the intensity of the crunch by holding and squeezing.
This study took 16 overweight men and women and split them into 2 groups. They then had each person in each group create the same sized caloric deficit and then consume that same calorie intake every day for 8 weeks. HOWEVER, they had one group eat 3 meals a day, and the other group eat 6 meals a day. Guess what happened? They all lost the same amount of weight. In fact, the study showed that there was no difference at all in fat loss, appetite control, or anything similar. Why? Because meal frequency doesn’t affect your ability to lose fat or gain fat. Calories do.

Routinely squeaking by on five hours or less per night increases visceral fat levels, according to a 2010 Wake Forest University study. What’s more, after analyzing 28 different studies, UK researchers found that people who slept 5.5 hours or less per night ate an extra 385 calories the day after compared to those who snoozed for at least 7 to 12 hours. On top of that, they preferred to munch on fatty foods full of empty calories, like chips.
The good news is that there’s increasing evidence that the brain can, in large part, “fix” itself once new behavior patterns emerge (i.e., calorie restriction, healthy food choices, and exercise). While there may be some degree of “damage” to the brain, particularly in how hunger and satiety hormones function, it can correct itself to a large degree over time. The key is that the process does take time, and like any other behavior change, is ultimately a practice. “We want to change behavior here,” says Hill. “Anyone that tells you it’s going to happen in 12 weeks, that’s bogus. We’re trying to rewire the brain. Neurobiology has told us so much about what’s going on in weight gain and weight loss. It takes a long time to develop new habits, rituals, routines. This takes months and years. But it will happen.”
You're more likely to stay slim if the view out your window includes hills, water, a park, or a street that leads to one of those things. In a North Carolina study, counties with more natural amenities, including mountains and lakes, had lower obesity rates. "It could be that there's something healing and calming about simply being outside," says Stephanie Jilcott Pitts, PhD, an assistant professor at East Carolina University. For instance, research has shown that people tend to be happier walking outdoors than inside. They also stride faster, yet feel less exertion, than they do on a treadmill. Not only that, hoofing it outside curbs cravings along with calories: In a study, regular chocolate eaters who took a brisk 15-minute stroll consumed about half as much of their favorite treat as those who didn't go for a walk. So take your workout outdoors. If your neighborhood isn't made for exercising, find a park nearby and head there as often as you can to bike, run, or hike.
The secret to a slimmer stomach in no time? A whole lot of fiber in your diet. Although many people are loath to add carbs to their diet when they’re trying to lose weight, adding the right, fiber-rich ones can have inches off your belly in a hurry. In fact, researchers at Wake Forest Baptist Medical Center found that every 10-gram daily increase in soluble fiber was associated with a 3.7 percent decrease in dangerous visceral fat over five years. Those who were active got even leaner, shaving off twice that much fat in the same amount of time. To start ditching that extra belly fat today, add the 30 Best Foods For Fiber to your menu!
Using a layered approach is another great way to build a good veggie habit. For example, start with a food you already enjoy — say, pasta — and layer some veggies into your bowl. This can help you explore a new food with one you already love eating, and from there, you can try new ways to savor it. Take spinach, for instance. After trying it with pasta, you may want fold it into an omelet or another favorite food, or explore it on its own with different cooking techniques (sautéed or steamed) or different flavor additions (garlic or golden raisins). The possibilities are limitless!
“I would focus on proteins from lean and minimally processed sources, two weekly servings of fish, carbohydrates from starchy vegetables, fruits, and legumes, and fats from plant-based sources,” says Feller. You’ll also want to stay seriously hydrated, as “water may help fill you up,” says Gans. Studies show that drinking just two glasses of water before a meal can help you consume less calories, and drinking throughout the day can keep you from misinterpreting thirst cues as hunger pangs.
It's typically harder to keep weight off than it is to lose it, the experts agreed. Many studies show that people usually experience their maximum weight loss after about six months of a diet-and-exercise program. After that, the pounds come creeping back, although most people don't regain all of the weight. For example, a 2007 review of 80 diet studies involving more than 26,000 people found that dieters lost about 11 to 19 lbs. (5 to 8.5 kg) after six months, but then their weight loss plateaued, and after four years, they maintained about 6.5 to 13 lbs. (3 to 6 kg) of weight loss.
You might have heard this a lot of time already that there is nothing like spot training or exercises. However, this is a biggest myth roaming around. It is obvious that spot exercises exist, for example you targets your biceps by following exercises such as barbell curl, preacher, hammer curl, and etc which are only designed for building biceps muscles then who exercises which targets belly area can’t provide results? There are certainly some which can provide great results when it comes to losing belly fat. Some of the well renowned spot belly fat exercises are.
A nice carbonated beverage can hit the spot when you’re thirsty. But you’ll have to skip the bubbles while you’re on a middle-shrinking mission—nutritionist Palin ski says the gas will make your belly poof up right away. Drink plain old tap water to stay hydrated—and make sure you get at least eight glasses a day. The special ingredients aren’t just there for flavor, either: The ginger helps calm and soothe your GI tract.
Some experts argue that instead of dieting leading to long-term weight gain, the relationship goes in the other direction: People who are genetically prone to gain weight are more likely to diet. To test this idea, in a 2012 study, researchers followed over 4,000 twins aged 16 to 25. Dieters were more likely to gain weight than their non-dieting identical twins, suggesting that dieting does indeed increase weight gain even after accounting for genetic background. The difference in weight gain was even larger between fraternal twins, so dieters may also have a higher genetic tendency to gain. The study found that a single diet increased the odds of becoming overweight by a factor of two in men and three in women. Women who had gone on two or more diets during the study were five times as likely to become overweight.
I'm confused that the author is promoting slow weight loss (which is a good thing, thank you for that) however the title of the book is Lose Weight Fast... so, you're misleading the reader by promising information on how to lose weight fast and then you're telling them nope, you're gonna lose it slow. Or, you're going to go ahead and tell them how to lose weight fast after you just said losing it fast is bad, which would be unethical. Either way, the title is misleading as it appears the author is taking the ethical road and teaching you how to lose weight slowly. Sorry to anyone expecting the title to be accurate here.
Answer \nDon't even think about it!\n\nThe other health risks from bulimia are terrible. Apart from every organ in your body being affected and risking them shutting down, it is not possible to be bulimic "for only three months"!\n\nBe more sensible. Eat a HEALTHY diet. Eat smaller quantities of food. And get up early and exercise! The combination of less food and more exercise will make the weight drop off.\n\nIf you starve yourself you will find you lose weight from your arms and legs and chest. Exercise will make the weight drop from your belly, bum and thighs.\n\nA person who is mildly overweight should be able to lose a kilogram a week - approximately 2 pounds.
As far as the measurement, yeah, those scales are garbage – but since it spits the data out, I figure I might as well right it down. I did a caliper test when I started and it gave me pretty similar results, but who knows. I am taking photos every week for my main source of tracking. I can see the progress there – and can definitely tell I have a lot of cutting yet to do! I’ll keep on pushing, I don’t know if I can hit 10%, but I will try for 12%.
Wonderful! I hate cardio. I have created a caloric deficit of about 500 calories, so I think I’m just going to do about 30 min of cardio on the days I don’t weight train. I think being at the gym once a day (5 or 6 days a week) helps my motivation. I have a treadmill at home but I don’t feel the same on it as I do in the gym surrounded by other fitness minded people. Looking forward to the cardio articles! BTW, an article on correct form for some basic exercises would be great for us beginners as well!
In a new study, Stanford University researchers put more than 600 overweight adults on either a healthy low-fat or low-carb diet. It turns out, participants had similar levels of weight loss success on each plan. Researchers looked for clues (such as insulin levels and gene patterns) to see if there are any factors that might make someone more successful on either diet, but after combing through the data, they were not able to make any connections. Since it may take years before scientists discover individual traits that could lead to more success on one plan compared to another, for now, we can learn a lot — and lose a lot! — by recognizing the dieting advice that all experts agree on.
My repeated dieting eventually caught up with me, as this research would predict. When I was in graduate school and under a lot of stress, I started binge eating. I would finish a carton of ice cream or a box of saltines with butter, usually at 3 a.m. The urge to keep eating was intense, even after I had made myself sick. Fortunately, when the stress eased, I was able to stop. At the time, I felt terrible about being out of control, but now I know that binge eating is a common mammalian response to starvation.
Obese people who consumed a tablespoon or two of vinegar daily for eight weeks showed significant decreases in body fat—particularly visceral fat—according to a 2009 Japanese study. "One theory is that the acetic acid in the vinegar produces proteins that burn up fat," explains Pamela Peeke, M.D., professor of medicine at the University of Maryland, author of Fight Fat After 40.
Women who ate low-fat dairy products, such as non-fat yogurt and low-fat cheese three to four times a day lost 70 percent more fat than low-dairy dieters, according to a study published in the journal Obesity Research. "Calcium serves as a switch that tells your body to burn excess fat faster," explains study author Michael Zemel, M.D., director of the Nutrition Institute at the University of Tennessee in Knoxville. Sorry, but you won't reap the same benefits from calcium-fortified O.J. Research shows that you get the best results from dairy products themselves, not fortified foods. Aim for 1,200 mg, which includes about three servings of dairy a day.

Fathi, Y., Faghih, S., Zibaeenezhad, M. J., & Tabatabaei, S. H. (2016, February). Kefir drink leads to a similar weight loss, compared with milk, in a dairy-rich non-energy-restricted diet in overweight or obese premenopausal women: A randomized controlled trial. European Journal of Nutrition, 55(1), 295–304. Retrieved from https://link.springer.com/article/10.1007/s00394-015-0846-9
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