Recent studies have shown more and more people are adding oatmeal to their daily routine diet. Oatmeal is considered best when it comes to having something which is enriched with soluble fiber. Apart from soluble fiber, oatmeal is another great source of protein. Plus, oatmeal can induce the feeling of fullness for a long period of time. In other words, it can suppress appetite.


Most people who want to lose weight have more than 12 pounds to lose. That’s why even the best weight loss drug in the world can only be an optional complement to other treatment. That’s why this piece of advice is number 18 out of 18. It may be a helpful addition for some people, but the advice higher on the list is what can make the biggest difference, by far.

You might feel silly, but it works. When Alan R. Hirsch, M.D., neurological director of the Smell & Taste Treatment and Research Foundation in Chicago, tried this with 3,000 volunteers, he found that the more frequently people sniffed, the less hungry they were and the more weight they lost—an average of 30 pounds each. One theory is that sniffing the food tricks the brain into thinking you’re actually eating it.
High blood sugar levels coupled with high blood ketones, on the other hand, will mean that you have a pathologically low level of insulin – something non-diabetics do not suffer from. This can lead to ketoacidosis – a potentially life-threatening condition. If this happens, you’ll need to inject more insulin; if you’re at all unsure of what to do, contact a medical professional. Coveting really high blood ketones for weight control is not worth the risk for type 1 diabetics.
If weight loss sounds like a lot of physical and mental work, that's because it is. And there's no magic pill: Dietary supplements that claim to help people lose weight have not been proven to work, and they have the potential to be dangerous, Cohen said. Many nutritionists and researchers agree that such supplements can do more harm than good. Supplements can contain drugs that are not listed on the label, and may have harmful side effects. In 2014, the Food and Drug Administration identified more than 30 weight loss supplements that contained hidden drugs, but only seven of these were recalled by their manufacturers.

You might have heard this a lot of time already that there is nothing like spot training or exercises. However, this is a biggest myth roaming around. It is obvious that spot exercises exist, for example you targets your biceps by following exercises such as barbell curl, preacher, hammer curl, and etc which are only designed for building biceps muscles then who exercises which targets belly area can’t provide results? There are certainly some which can provide great results when it comes to losing belly fat. Some of the well renowned spot belly fat exercises are.
One of the best plank variations involves crawling. This exercise routine helps you tone your abs, back, and shoulders. Crawls are designed to use the upper and lower body in unison. To do a plank crawl you need to get in a pushup position, then lowering yourself down into the plank position by balancing on your forearms, elbows and toes. Now balance on one arm the come back to your initial push-up position, repeat the process by alternating the arm. You have to maintain a straight body during the exercise routine. Plank is commonly practiced in Pilates and yoga. You can decrease the difficulty level by lowering your knees to the floor.
The one that concerned me after reading this was the lancet. According to the website, 3 groups of people had 3 different diets, each diet only containing 1000 calories. One was 90% of calories from carbs, one 90% of calories from fat, and one 90% of calories from protein. In the end, the group that ate 90% fat lost the most average weight, and the group that ate 90% carbs ended up gaining weight on average. How does this make sense if they all had the same calorie intake?
We know that this type of fat—called visceral fat—churns out stress hormones like cortisol and inflammatory substances called cytokines that affect the body's production of insulin. The result: Besides obesity, you're also looking at increased risks of type 2 diabetes and heart disease. No thanks. Check out these nine tips to finally rid your body of that excess stomach.
Often times losing weight goes hand in hand with a newfound love, or simply a routine of exercise. Many decide to purchase exercise equipment for their homes, or for when they're traveling so that they don't have to stray from their goals and routine. Dumbbells, benches, cardio machines, mats, and workout DVDs are just a few examples of beneficial, yet costly equipment that will assist with weight loss and weight maintenance goals.
It sounds silly, but switching which hand you eat with can save you calories, and help boost weight loss. “It takes 15 minutes for your brain to realize that you’re full,” celebrity personal trainer Jay Cardiello told us in our article 40 Weight Loss Tips for Over 40. “To give your mind time to catch up to your mouth, simply switch your fork to non-dominate hand. It may be frustrating, but it’s a simple and unnoticeable way to curb overeating and lose weight.”
It's typically harder to keep weight off than it is to lose it, the experts agreed. Many studies show that people usually experience their maximum weight loss after about six months of a diet-and-exercise program. After that, the pounds come creeping back, although most people don't regain all of the weight. For example, a 2007 review of 80 diet studies involving more than 26,000 people found that dieters lost about 11 to 19 lbs. (5 to 8.5 kg) after six months, but then their weight loss plateaued, and after four years, they maintained about 6.5 to 13 lbs. (3 to 6 kg) of weight loss.
This study took 83 subjects, estimated the daily calorie requirements of each person (aka their maintenance levels), and then created a caloric deficit of 30%. They then divided them up into 3 groups. The first had only 4% of their total daily calorie intake coming from carbs. The second had 50% of their total calorie intake coming from carbs. The third had 70% of their total calorie intake coming from carbs. Guess what happened? Even though some people were eating a VERY LOW carb diet and others were eating a VERY HIGH carb diet… they all lost the same amount of weight and body fat. Why? Because low carb or high carb isn’t what makes us gain or lose fat. Calories are, regardless of how many of them come from carbs.
Use MyPlate’s calculator to find your recommended daily caloric intake at https://www.choosemyplate.gov/MyPlate-Daily-Checklist-input. Enter your age, sex, height, weight, and activity level. The calculator will list how many calories you should consume to maintain your current weight and how many you should cut from your diet to get to a healthy weight.
53. Prep Meals For The Week On Sundays – Cooking at home can mean increased food quality and greater awareness of what ingredients you’re actually eating. This is helpful in controlling how much protein, fat, and calories you’re eating on a daily basis. People who prepare food at home also tend to eat more fruits and vegetables. Start preparing healthy meals over the weekend so you can don’t have to think about what to eat for lunch or dinner during the week.
If your BMI places you in the obese category, it's time to lose weight, according to the most recent (2013) weight management guidelines from the American Heart Association and other professional organizations. Weight loss is also recommended if you're overweight and have other risk factors for heart disease, such as diabetes, high blood pressure, high cholesterol levels, or a waist circumference greater than 35 inches (88 centimeters) for women and 40 inches (102 centimeters) for men.

There’s one thing to like about visceral fat: It yields fairly easily to aerobic exercise. Vaporizing calories via running, biking, swimming—anything that gets your heart rate up—is an effective way to whittle your middle. In fact, one 2011 study from Duke University Medical Center, published in the American Journal of Physiology, found the sweet spot: Jogging the equivalent of 12 miles a week was even more effective in reducing visceral fat than resistance training three times per week. However, both types of exercise were beneficial when it came to belly fat, the researchers say. (Don’t have time to hit the gym? Try these fun at-home cardio workouts if you’re in a pinch.)
Weight loss is a mathematical equation: you simply need to take in fewer calories (of whatever you prefer to eat) than you use each day. So, yes, you could still lose weight. That said, you won't be a healthy "thin" if you don't nourish your body with good, whole foods, including plenty of fresh fruits and vegetables. Plus, fruits and veggies aid in weight loss by helping you to feel full (taking up the space in your stomach you might be tempted to devote to less healthy options).
In addition to improving your health, maintaining a weight loss is likely to improve your life in other ways. For example, a study of participants in the National Weight Control Registry* found that those who had maintained a significant weight loss reported improvements in not only their physical health, but also their energy levels, physical mobility, general mood, and self-confidence.

Studies reveal that foods made from refined white flour are the significant causes of visceral fat. Added sugar has a high content of fructose. Sweetened drinks such as fruit juices, sodas, and other soft drinks can increase the amount of belly fat. You should also avoid desserts, candy, and pastries because they contain a lot of sugar. In case you crave for sweets and other sugary food, replace them with more nutritious food like nuts, yogurt or fruits.
But you’ll likely experience some benefit before then. Fiber helps slow down your digestion and requires more chewing, which helps signal to your body that it’s full, keeping your hunger in check throughout the day. One small study published in Food & Nutrition Research actually found that men who ate meals rich in high-fiber foods, like beans and peas, felt more satisfied than those who focused only on protein-rich foods, like pork and veal. Adult women should aim to eat 25 to 28 grams of fiber per day.
Walking of any kind is one of the best ways to lose weight, but stairs in particular work wonders for weight loss. The Centers for Disease Control says that 10 minutes walking on stairs is all it takes to help you shed as much as 10 pounds a year (assuming you don’t start eating more). Check out these other tricks for squeezing in more steps every day.
It's recommended that adults should try to be active every day and should complete at least 150 minutes of moderate aerobic exercise per week - this could include cycling or walking at a fast pace. Alternatively, you could complete 75 minutes of vigorous aerobic exercise, which could include running or a game of football. You could split this up into easily manageable 30-minute workouts over 5 days of the week.

Consume about 50 gr of carbohydrate for a breakfast. Low carb diets are usually essential, if you wish to lose fat sooner. One cup with oatmeal has 50 gr of carbohydrate. For other meals in the day consume toned protein about the length of your fist. Feel free to use whey protein, yoghurt, fresh vegatables and fruits as snacks. Limit the consumption of fat to coconut oil or fish petroleum. Avoid using mayonnaise, margarine, butter, many other vegetable oils or anything else. You can start exercise like breathing squat to take out the belly body fat.

Not far into the book they want you to listen to a infomercial. I learned that my doctor is a lying stinking jerk. Apparently he, and ALL doctors, know the secret of losing weight fast and easy but they, and their diet professional, do not want to share it or they will lose money when we get thin and healthy. I also learned that to lose weight I do not have to eat less or exercise more. It’s just bad science that taught us that rubbish…and again All doctors know this. The majority of overweight people are not overweight because of eating in excess or not exercising enough, it’s because they have chronic cellular inflammation.
Why you're gaining back the weight section is both complimentary and contradictory to the last section of common mistakes. In common mistakes the author tells you not to check the scale so often, in why you're gaining it back, it's because you're not checking the scale enough. Then it repeats the issues with crash diets (this is why they don't work, I agree with this completely). There is a brief paragraph on emotional eating, and I really wish this was talked about even more, but it's not.

Everyone’s body is different when it comes to digesting some gas-forming foods, but there are a few you should be wary of: It’s best to avoid beans and cruciferous veggies (think cabbage, Brussels sprouts, cauliflower, and broccoli) for a couple of days if you want to look slimmer. Choose lean proteins like chicken and fish or, if you’re vegetarian, go for small amounts of nuts and seeds for protein. Pair with non-gassy vegetables like asparagus, spinach, and cucumber to help prevent bloat.


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There's no magic number or one-size-fits-all recommendation, but doing a few calculations can give you an idea of how many calories you should eat for weight loss. First, figure out your basal metabolic rate (BMR), which is how many calories your body burns at rest, by just keeping basic functions running (like breathing). Experts use a formula called the Mifflin St. Jeor equation: (10 x your weight in kilograms) + (6.25 x your height in centimeters) – (5 x your age in years) – 161. You can also get your BMR measured at an endocrinologist's office. Then, factor in your activity level—try using this interactive calculator from the United States Department of Agriculture, which will give you a rough estimate of how much you should eat to maintain your current weight considering your BMR and activity level. To lose weight, you need to cut calories from that base number, either by deleting intake or increasing output. "Losing 1 to 2 pounds per week is reasonable, safe, and healthy for most," Cederquist says. Since 1 pound of fat is around 3,500 calories, you'd need to achieve a 500-calorie deficit each day to lose 1 pound each week.
I am a meso-endo body type and I need to lose body fat!! I have been doing HIIT and weights, but lately I have been thinking of starting power walking instead of HIIT(jump squats, burpees, pushups, jumping lunges) and weights which I think they bulk me. I have quite muscular legs and wide upper body but it is covered with excess fat. I eat very healthily, low carb mostly, but I cannot lose fat. Should I stop doing hiit and strength type of training and focus os power walking? Also, is running going to help? I am afraid that by not doing any resistant training I will slow down my metabolism and not burn fat. But I have very strong legs I feel that I need to lose fat in order for them to seem toned. I have excess fat all over my body, what should I do??? Thank you in advance!!
Running keeps your heart beat racing and helps you burn a considerable amount of calories, ultimately leading to weight loss. But even a moderate rate jog which you can definitely spare for a few times a week, helps in belly fat loss. Data collected from a study conducted over a period of eight months at Duke University Medical Center revealed that overweight adult participants who jogged about 19 km a week lost the most belly fat, burning 67 per cent more calories than participants who performed an equivalent amount of resistance training or a combination of cardio along with resistance workouts.
Love your site and all your knowledge leads me to believe you may be able to help. I am STUCK. Can’t lose a pound. I am 5’6″, 126#, and have calculated my maintenance calories at 1850/day. I am eating this (or less) and working out as follows. Three times per week I do 55 minutes of cardio on the Arc Trainer (1050 calories, 4.2miles, according to the meter) followed by one hour of weights. Two times per week I take a Zumba or Pole class followed by a stretching and flexibilty class. By my calculation I should be burning a TON of fat but my scale hasn’t moved in months. Please help!

According to a study, people who snoozed past 10.45 am were more likely to consume 250 extra calories in their meals throughout the day. Additionally they leaned towards sugary, salty and trans-fat laden foods as compared to their early bird counterparts. Researchers from Northwestern University revealed that early risers received an additional metabolic boost and people who were exposed to just a short period of early morning sunlight had lower BMI compared to people who woke up late.
Getting enough protein every day, whether you’re in a quick-fix or long-term mindset is important for keeping your muscles and metabolism healthy throughout weight loss. Make sure you’re having some chicken breast, lean ground turkey, fish, seafood or tempeh that’s the size of a deck of cards at every meal. When snacking, have 2 eggs, 1/4 cup of nuts, or 3/4 cup of Greek yogurt or cottage cheese to meet your protein needs and stay full and feel slim.

Trying to lose weight is a lot like cleaning out the basement: It’s overwhelming and near impossible to know where to start—even when you don’t have a ton of weight to lose. But getting the body you’ve always wanted doesn’t have to be a source of stress. If the scale won’t budge and you’re looking to shed the last 10 pounds, there are plenty of ways to reach your goal. To help you get there, we spoke with a handful of celebs that have successfully slimmed down (and kept it off) and dozens of the fitness and diet industries top experts.
There is some scientific legitimacy to today’s lower-carb diets: Large amounts of simple carbohydrates from white flour and added sugar can wreak havoc on your blood sugar and lead to weight gain. While avoiding sugar, white rice, and white flour, however, you should eat plenty of whole-grain breads and brown rice. One Harvard study of 74,000 women found that those who ate more than two daily servings of whole grains were 49 percent less likely to be overweight than those who ate the white stuff. Eating whole grains is not only one of many great ways to lose weight; it can also make you smarter.
You’ve heard of a self-fulfilling prophecy? If you keep focusing on things you can’t do, like resisting junk food or getting out the door for a daily walk, chances are you won’t do them. Instead (whether you believe it or not) repeat positive thoughts to yourself. “I can lose weight.” “I will get out for my walk today.” “I know I can resist the pastry cart after dinner.” Repeat these phrases and before too long, they will become true for you. Try these other daily mantras that can help you reach your goals.
There's a reason you've been hearing so much about cutting meat out of your diet lately. It's not just great for your body, but also a quick way to shed some extra pounds. "Consider swapping a few meat-centric meals each week for ones centered around vegetarian proteins — or give a full-fledged vegetarian diet a try if that's of interest to you," Gorin says. "Research shows eating a vegetarian diet may boost and speed up weight loss, resulting in a loss of up to 10 pounds." Gorin recommends topping a salad or filling a veggie taco with vegetarian protein sources like pulses — which are beans, chickpeas, lentils, and dried peas — to give your weight loss a boost. One study found eating ¾ cup of pulses daily led to a loss of close to a pound over about six weeks, versus people not eating pulses daily.
In the laboratory, rodents learn to binge when deprivation alternates with tasty food — a situation familiar to many dieters. Rats develop binge eating after several weeks consisting of five days of food restriction followed by two days of free access to Oreos. Four days later, a brief stressor leads them to eat almost twice as many Oreos as animals that received the stressor but did not have their diets restricted. A small taste of Oreos can induce deprived animals to binge on regular chow, if nothing else is available. Repeated food deprivation changes dopamine and other neurotransmitters in the brain that govern how animals respond to rewards, which increases their motivation to seek out and eat food. This may explain why the animals binge, especially as these brain changes can last long after the diet is over.

… that lists sugar, fructose, or corn syrup among the first four ingredients on the label. You should be able to find a lower-sugar version of the same type of food. If you can’t, grab a piece of fruit instead, especially if you show signs you’re eating too much sugar. Look for sugar-free varieties of foods such as ketchup, mayonnaise, salad dressing, and these other foods with way more sugar than you realize. Also, avoid partially hydrogenated foods, and look for more than two grams of fiber per 100 calories in all grain products. Finally, a short ingredient list means fewer flavor enhancers and empty calories. Sounds impossible, but you can actually learn how to give up sugar without missing it.
SIX years after dropping an average of 129 pounds on the TV program “The Biggest Loser,” a new study reports, the participants were burning about 500 fewer calories a day than other people their age and size. This helps explain why they had regained 70 percent of their lost weight since the show’s finale. The diet industry reacted defensively, arguing that the participants had lost weight too fast or ate the wrong kinds of food — that diets do work, if you pick the right one.
Plus, it’s way more likely that you’re losing lean muscle mass over fat. “Muscle is more metabolically active than fat, meaning it takes the body more calories at rest to maintain muscle,” explains Feller. “When a person loses weight quickly, the body begins to break down that muscle.” And since you don’t want to drop your muscle mass, it’s clearly not the smart way to go. (After All, Just Look at These Women Who Prove Being Strong Is Dead Sexy.)
Call it what you will: An eating plan, a lifestyle, a diet, a philosophy, but few things garner such heated debate as how to lose weight. The truth is, whether you’re on a low-carb keto program, devoted to the Paleo lifestyle, all in to the Whole 30 or remain committed to low-fat eating, these plans have more in common than you think. What’s more, follow any one of them religiously, and you’ll likely notice results.
Are you finding it difficult to fit into your little black number? Is belly fat giving you sleepless nights? If your answer is yes, you need to make some lifestyle changes to get the figure of your dreams. No doubt, belly fat looks aesthetically displeasing. It can assume serious proportions and affect long term health, if not curbed at the right time.
In the first chapter the author doesn't take long to start body shaming people. In the section of how obesity is measured the author tells you that if you have unequal distribution of fats, if you have a protruding tummy or bulging thighs it can make you look unattractive. Gee, thanks for the judgement there. Let's keep it to the facts and not the attractiveness opinions of others. Really, another person's opinion of how attractive I am based on my body shape is not a good measurement of obesity.
Hey Ken, happy you liked the article. I wouldn’t rely on the MyFitnessPal calorie intake / burn calculator. In general, calore intake calculators tend to overestimate calorie intake. I would stick to your target calorie intake even if you happen to do a little more exercise, or more activity. That’s my opinion. What I do with private training clients is use the Katch & McArdle method to arrive at estimated calorie burn, then subtract about 30-35% to create the estimated calorie intake. Another option, which is easier and similar, is just to multiply your weight x 10 for the calorie intake, which assumes 3 to 5 workout sessions. For more info, you can check out my article How to Calculate Calorie Burn.
You must have noticed that some of your friends eat a lot of sugar-based foods, fried foods, or cold drinks. Yet, they manage to have a flat stomach, the reason being they have a very high metabolic rate. If your metabolism is not good, you may have a bloated stomach. Thyroid conditions, diabetes, and other medical conditions can be the reasons for slow metabolism.
Have Protein at Every Meal and Snack. Adding a source of lean or low-fat protein to each meal and snack will help keep you feeling full longer so you're less likely to overeat. Try low-fat yogurt, small portion of nuts, peanut butter, eggs, beans, or lean meats. Experts also recommend eating small, frequent meals and snacks (every 3-4 hours), to keep your blood sugar levels steady and to avoid overindulging.
While some people respond well to counting calories or similar restrictive methods, others respond better to having more freedom in planning their weight-loss programs. Being free to simply avoid fried foods or cut back on refined carbs can set them up for success. So, don’t get too discouraged if a diet that worked for somebody else doesn’t work for you. And don’t beat yourself up if a diet proves too restrictive for you to stick with. Ultimately, a diet is only right for you if it’s one you can stick with over time.
The reason we’re suggesting 45 minutes instead of the typical 30 as one of the ways to lose weight is that a Duke University study found that while 30 minutes of daily walking is enough to prevent weight gain in most relatively sedentary people, exercise beyond 30 minutes results in weight and fat loss. Burning an additional 300 calories a day with three miles of brisk walking (45 minutes should do it) could help you lose 30 pounds in a year without even changing how much you’re eating. If you need motivation, try these secrets of women who work out every day.

Take more with boiled or raw vegetables this very day. You can employ thin vegetable and chicken soup to lower belly fat. Make certain you consume something every 2-3 hours. This raises your metabolic charge and stabilize the blood glucose levels. Taking five to help six servings of vegatables and fruits will prevent yearnings for food. Stay away from high carb fresh fruits like banana, apple company company etc. If you will be a person which regularly does activities, you can keep going your exercises and these changes inside diet. If you've got not started training, start with delicate exercises like wandering for 20 a matter of minutes.
29. Don’t Make Excuses, Just Start Working Out – If you’re tired, don’t think too much about it. Put your headphones on and just start moving. Do a dynamic warm-up to get yourself in the mindset, and start with easier exercise sets. You can keep your workout low-key if you’re tired or stressed, and you can go hard when you’re full of energy. You never regret a workout, but you might regret skipping one.
Getting enough protein every day, whether you’re in a quick-fix or long-term mindset is important for keeping your muscles and metabolism healthy throughout weight loss. Make sure you’re having some chicken breast, lean ground turkey, fish, seafood or tempeh that’s the size of a deck of cards at every meal. When snacking, have 2 eggs, 1/4 cup of nuts, or 3/4 cup of Greek yogurt or cottage cheese to meet your protein needs and stay full and feel slim.

Simply take a good hard look at your diet, make a few modifications you can stick with and get your body moving. Not sure where you stand on diet? Write down everything you eat this week, then compare it to the list above and see where you could have made better choices. Don’t beat yourself up though, learning how to lose stomach fat fast is a process. Simply find areas to improve and work on them next week.
Using a layered approach is another great way to build a good veggie habit. For example, start with a food you already enjoy — say, pasta — and layer some veggies into your bowl. This can help you explore a new food with one you already love eating, and from there, you can try new ways to savor it. Take spinach, for instance. After trying it with pasta, you may want fold it into an omelet or another favorite food, or explore it on its own with different cooking techniques (sautéed or steamed) or different flavor additions (garlic or golden raisins). The possibilities are limitless!
Ultimately, weight loss for the long-term requires some short-term behavior change and healthier habit formation. That's why we created our Good Housekeeping Nutritionist Approved Emblem, which exists to help turn smart food choices into healthier eating habits. All GHNA foods and drinks make it easier to find — and eat — good-for-you foods without additional time, effort, and cost. We target the lifestyle-related factors that make healthier eating hard, and find simple but creative solutions that actually work! Look for the emblem on labels wherever you shop for food!
43. Eat Fermented Foods – Foods like kimchi, sauerkraut, kefir, and yogurt can help to curb sweet cravings while also improving gut health. Believe it or not, eating fermented foods has also been found to improve blood pressure and body composition.45 Fermented vegetables aren’t your only option either. You can also include fermented drinks like kombucha, coconut water kefir, and kvass.
In what is perhaps the biggest buzzkill of all time, sex doesn’t quite count as cardio or burn a significant amount of calories: Women burn about 3.6 per minute. “It’s still a good idea,” Dr. Seltzer says, citing the activity’s other benefits, like increasing the output of the neurotransmitters serotonin and dopamine, which naturally reduce food cravings.
We often make the wrong trade-offs. Many of us make the mistake of swapping fat for the empty calories of sugar and refined carbohydrates. Instead of eating whole-fat yoghurt, for example, we eat low- or no-fat versions that are packed with sugar to make up for the loss of taste. Or we swap our fatty breakfast bacon for a muffin or donut that causes rapid spikes in blood sugar.

That's why one of the most widely used gauges of whether a person needs to shed pounds is body mass index (BMI) — an indicator of body fatness developed by Belgian statistician Adolphe Quetelet in 1832 that's based on the ratio of height to weight. For example, a person who is 5 feet 7 inches (1.7 meters) and weighs 172 lbs. (78 kg) would have a BMI of 27. [BMI Calculator: What's My BMI]

Harvie, M. N., Pegington, M., Mattson, M. P., Frystyk, J., Dillon, B., Evans, G., … Howell, A. (2011, May). The effects of intermittent or continuous energy restriction on weight loss and metabolic disease risk markers: A randomized trial in young overweight women. International Journal of Obesity (London), 35(5), 714–727. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3017674/
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